- Title
- Airway epithelial-derived exosomes induce acute asthma exacerbation after respiratory syncytial virus infection
- Creator
- Yao, Ye; Yang, Yu; Du, Xizi; Wang, Leyuan; Zhou, Kai; Wu, Xinyu; Wang, Weijie; Qing, Bei; Xiang, Yang; Qu, Xiangping; Yang, Ming; Qin, Xiaoqun; Ji, Ming; Liu, Chi; Qin, Qingwu; Xu, Kun; Xia, Zhenkun; Liu, Huijun; Yuan, Lin; Yuan, Yunchang; Qin, Ling
- Relation
- MedComm Vol. 5, Issue 7, no. e621
- Publisher Link
- http://dx.doi.org/10.1002/mco2.621
- Publisher
- John Wiley & Sons
- Resource Type
- journal article
- Date
- 2024
- Description
- Acute asthma exacerbation refers to the progressive deterioration of asthma symptoms that is always triggered by virus infection represented by respiratory syncytial virus (RSV). After RSV infection, exaggerated Th2-mediated pulmonary inflammation is the critical pathological response of asthmatic patients with acute exacerbation. Significantly, airway epithelial cells, being the primary targets of RSV infection, play a crucial role in controlling the pulmonary inflammatory response by releasing airway epithelial cell-derived exosomes (AEC-Exos), which potentially influence the development of asthma. However, the specific role of AEC-Exos in acute asthma exacerbation after RSV infection remains obscure. The purpose of this study was to determine the distinct function of AEC-Exos in exacerbating acute asthma following RSV infection. Blockade of exosomes by GW reduce the enhanced pulmonary inflammation significantly. Specifically, the enhanced Th2 inflammation was induced by AEC-Exos thorough transportation of hsa-miR-155-5p–Sirtuin 1 (SIRT1) pathway during acute asthma exacerbation. Targeted inhibition of hsa-miR-155-5p blocks the exaggerated Th2 inflammation effectively in mice with acute asthma exacerbation. In summary, our study showed that during acute asthma exacerbation after RSV infection, AEC-Exos promote the enhanced Th2 inflammation through transportation of increased hsa-miR-155-5p, which was mediated partly through SIRT1-mediated pathway. hsa-miR-155-5p is a potential biomarker for early prediction of acute asthma exacerbation.
- Subject
- acute asthma exacerbation; airway epithelial cells; exosomes; respiratory syncytial virus; Th2 inflammation; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1509600
- Identifier
- uon:56270
- Identifier
- ISSN:2688-2663
- Rights
- x
- Language
- eng
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